FDG PET/CT Imaging and Circulating Biomarkers of Inflammation in Desmoplakin Cardiomyopathy
In a group of ambulatory patients with DSP and titin cardiomyopathy, we found no differences in FDG PET/CT findings or clinical circulating biomarkers of inflammation. However, miRNA-seq/proteomics analyses identified several enriched pathways and unique miRNA-protein pairs between DSP and titin cardiomyopathy, including pathways involved in inflammasome/inflammatory signalling. Future work will centre on evaluation during myocarditis-like episodes.
Authors
- Usman A. Tahir (ORCID: https://orcid.org/0000-0002-3657-6082)
- Mark W. Feinberg (ORCID: https://orcid.org/0000-0001-9523-3859)
- Anna Perillo (ORCID: https://orcid.org/0009-0009-0083-2759)
- Sanjay Divakaran (ORCID: https://orcid.org/0000-0003-0598-6502)
- Leanne Barrett (ORCID: https://orcid.org/0000-0003-0667-8720)
- Vinay Randhawa (ORCID: https://orcid.org/0000-0002-5070-6218)
- Marcelo F. Di Carli (ORCID: https://orcid.org/0000-0003-3119-025X)
- Anam Waheed
- Matthew Robertson (ORCID: https://orcid.org/0000-0003-1291-4654)
- Ron Blankstein
- Neal K. Lakdawala
Institutions
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- MedStar Health (US)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1002/ehf2.15154
- Citations
- 3
- Primary Topic
- Cardiovascular Effects of Exercise
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Brigham and Women's Hospital