WELL-POSEDNESS AND CONVERGENCE ANALYSIS OF THE MULTI-LEVEL MONTE CARLO METHOD FOR A SYSTEM OF PDEs WITH RANDOM COEFFICIENTS MODELING DRUG TRANSPORT IN TUMORS

In this paper, we consider a mathematical model of drug transport in tumors given by a system of PDEs with random coefficients and initial data. The existence of a strong solution to this model in any dimension is proved under the assumption that the random coefficients are uniformly bounded. Along with the finite difference method (FD), we applied a multilevel Monte Carlo method to simulate these random PDEs. We also derived the overall convergence rate and estimated the total computation cost. Finally, some numerical results are presented to confirm our theoretical results. Additionally, we provide a comparison between the stochastic and deterministic approaches for solving the drug transport equation, demonstrating the efficiency of the method we adopted.

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Publication Details

Journal
Advanced mathematical models & applications.
Published
2024-12-04
DOI
https://doi.org/10.62476/amma93454
Primary Topic
Mathematical functions and polynomials
Type
article
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article

WELL-POSEDNESS AND CONVERGENCE ANALYSIS OF THE MULTI-LEVEL MONTE CARLO METHOD FOR A SYSTEM OF PDEs WITH RANDOM COEFFICIENTS MODELING DRUG TRANSPORT IN TUMORS

Saadeddine Essarrout
Advanced mathematical models & applications.
Mathematical functions and polynomials
article

WELL-POSEDNESS AND CONVERGENCE ANALYSIS OF THE MULTI-LEVEL MONTE CARLO METHOD FOR A SYSTEM OF PDEs WITH RANDOM COEFFICIENTS MODELING DRUG TRANSPORT IN TUMORS

Saadeddine Essarrout
article en

Abstract

In this paper, we consider a mathematical model of drug transport in tumors given by a system of PDEs with random coefficients and initial data. The existence of a strong solution to this model in any dimension is proved under the assumption that the random coefficients are uniformly bounded. Along with the finite difference method (FD), we applied a multilevel Monte Carlo method to simulate these random PDEs. We also derived the overall convergence rate and estimated the total computation cost. Finally, some numerical results are presented to confirm our theoretical results. Additionally, we provide a comparison between the stochastic and deterministic approaches for solving the drug transport equation, demonstrating the efficiency of the method we adopted.

Advanced mathematical models & applications.Vol. 9(3)
Good health and well-being
Openalex Percentile: Top 63%
Mathematical functions and polynomials
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WELL-POSEDNESS AND CONVERGENCE ANALYSIS OF THE MULTI-LEVEL MONTE CARLO METHOD FOR A SYSTEM OF PDEs WITH RANDOM COEFFICIENTS MODELING DRUG TRANSPORT IN TUMORS — Saadeddine Essarrout · Advanced mathematical models & applications. (2024) | TGRS Research Map | TGRS