Metformin Modulates Cell Oxidative Stress to Mitigate Corticosteroid-Induced Suppression of Osteogenesis in a 3D Model
Metformin exhibits promising therapeutic potential beyond its role in diabetes management. The capacity to alleviate oxidative stress highlights the potential of metformin in supporting bone formation in inflammatory environments.
Authors
- Issei Shinohara (ORCID: https://orcid.org/0000-0002-4122-7119)
- Stuart B. Goodman (ORCID: https://orcid.org/0000-0002-1919-3717)
- Bruce A. Bunnell (ORCID: https://orcid.org/0000-0001-6196-3722)
- Simon Kwoon‐Ho Chow (ORCID: https://orcid.org/0000-0003-1742-980X)
- Alexa K. Pius
- Hang Lin (ORCID: https://orcid.org/0000-0002-0781-6630)
- Masatoshi Murayama (ORCID: https://orcid.org/0009-0000-1228-482X)
- Qi Gao (ORCID: https://orcid.org/0000-0003-0175-566X)
- Yosuke Susuki (ORCID: https://orcid.org/0009-0002-1458-4361)
- Yasemin Sude Ergul (ORCID: https://orcid.org/0000-0002-1683-9439)
- Chao Ma
- Mehmet Sertac Cekuc (ORCID: https://orcid.org/0000-0002-8068-7820)
- Mayu Morita (ORCID: https://orcid.org/0009-0003-8092-0762)
- Makarcyzk Meagan
Institutions
- University of North Texas (US)
- University of North Texas Health Science Center (US)
- University of Pittsburgh (US)
- Orthopaedic Research Laboratories (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s498888
- Citations
- 4
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Institutes of Health