TTF-1 negativity in synchronous M1b/M1c wildtype lung adenocarcinoma brain metastases predicts worse survival with increased risk of intracranial progression
In synchronous LUAD brain metastases, TTF-1 negativity reflects an aggressive phenotype with larger proliferation capacity and tumor volume. Future research should explore the underlying cellular and molecular alterations of this phenotype.
Authors
- Helena Radbruch (ORCID: https://orcid.org/0000-0001-6941-3397)
- Peter Vajkoczy (ORCID: https://orcid.org/0000-0003-4350-392X)
- Nadja Jung
- Jan Bukatz
- Atik Baborie
- R. Ates
- Katharina Faust (ORCID: https://orcid.org/0000-0001-9969-0141)
- Philip Bischoff (ORCID: https://orcid.org/0000-0002-4442-7116)
- Nikolaj Frost (ORCID: https://orcid.org/0000-0001-7452-7129)
- David Capper (ORCID: https://orcid.org/0000-0003-1945-497X)
- Nils Ole Schmidt (ORCID: https://orcid.org/0000-0001-6910-8843)
- David Horst (ORCID: https://orcid.org/0000-0003-4755-5743)
- Julia Onken (ORCID: https://orcid.org/0000-0002-2859-4395)
- Markus J. Riemenschneider (ORCID: https://orcid.org/0000-0001-7658-1022)
- Anton Früh (ORCID: https://orcid.org/0000-0002-2982-2046)
- Martin Witzenrath
- Frank L. Heppner (ORCID: https://orcid.org/0000-0001-9816-8917)
- Martin Proescholdt
- Majd Abdulhamid Samman
- David Wasilewski
- Tommaso Araceli
- Selin Murad
- Julia Jünger
- Arend Koch
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- King Fahd Medical City (SA)
- University Hospital Regensburg (DE)
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1007/s11060-024-04885-y
- Citations
- 4
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Charité – Universitätsmedizin Berlin
- Deutschen Konsortium für Translationale Krebsforschung
- Berlin Institute of Health