IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway
This study identifies the protective role of IRGM in sepsis-induced ALI and reveals that IRGM mitigates ALI by promoting autophagy through inhibition of the AKT/mTOR pathway. These findings provide insights into the pathogenesis of sepsis-related ALI and highlight IRGM as a potential therapeutic target.
Authors
- Yu Xia (ORCID: https://orcid.org/0000-0002-5596-5518)
- Jianjun Liu (ORCID: https://orcid.org/0000-0002-3255-3019)
- Lei Zhang (ORCID: https://orcid.org/0000-0002-6968-0492)
- Na Guo (ORCID: https://orcid.org/0009-0003-8137-5700)
- Huixin Cheng (ORCID: https://orcid.org/0000-0002-4319-3397)
- Nannan He (ORCID: https://orcid.org/0000-0001-7648-3131)
Institutions
- Gansu Provincial Maternal and Child Health Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s496687
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.55