Mitochondrial metabolic reprogramming of macrophages and T cells enhances CD47 antibody-engineered oncolytic virus antitumor immunity
Tumor acidic microenvironment impairs mitochondrial energy metabolism in macrophages and T cells inducing oAd-αCD47 immunotherapeutic resistance. NaBi improves the acidity of the TME and activates the CaMKII/CREB/PGC1α mitochondrial biosynthesis signaling pathway, which reprograms the energy metabolism of macrophages and T cells in the TME, and oral NaBi enhances the antitumor effect of oAd-αCD47.
Authors
- Anliang Huang
- Shichuan Hu
- Xiangyu Long (ORCID: https://orcid.org/0000-0001-5461-3118)
- Zhongbing Qi (ORCID: https://orcid.org/0009-0003-4712-5097)
- Ping Cheng (ORCID: https://orcid.org/0000-0001-5440-5941)
- Jingyi Zhao (ORCID: https://orcid.org/0000-0002-2418-716X)
- Xiaobo Xu (ORCID: https://orcid.org/0000-0002-4420-4369)
- Jiyan Liu (ORCID: https://orcid.org/0000-0003-4885-5481)
Institutions
- Sichuan University (CN)
- Guang Fu Hospital (CN)
- Chengdu Fifth People's Hospital (CN)
- State Key Laboratory of Biotherapy
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/jitc-2024-009768
- Citations
- 7
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.85
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation