Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18
oAdDR18 demonstrates enhanced antitumor activities through the induction of stronger local and system immunities and modulation of the tumor microenvironment compared with those of oAdwtIL-18 and rDR18. A combination of oncolytic virotherapy with cytokine engineering would lead to cytokine-based therapeutics for cancer and other diseases.
Authors
- Erguang Li (ORCID: https://orcid.org/0000-0002-3065-1336)
- Susu He (ORCID: https://orcid.org/0000-0003-0035-0003)
- Yuqing Miao (ORCID: https://orcid.org/0000-0002-8330-2666)
- Dongge Xu
- Dwayne G. Stupack (ORCID: https://orcid.org/0000-0003-4396-5745)
- Yang Liu (ORCID: https://orcid.org/0000-0002-9442-700X)
- Yichi Zhang (ORCID: https://orcid.org/0000-0003-3932-3088)
- Yayi Hou (ORCID: https://orcid.org/0000-0002-1152-9132)
- Weikang Sun
- Yuanhui Zhao
- Yan Cheng (ORCID: https://orcid.org/0009-0004-4303-9789)
- Mengyu Zhang
Institutions
- Nantong University (CN)
- University of California San Diego (US)
- Shanghai Cancer Institute (CN)
- Yancheng First People's Hospital (CN)
- Yancheng Third People's Hospital (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/jitc-2024-009716
- Citations
- 4
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.20
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province