Differences in splicing factors may predict type 2 diabetes remission in the CORDIOPREV study
Alternative splicing is a post-transcriptional process resulting in multiple protein isoforms from a single gene. Abnormal splicing may lead to metabolic diseases, including type 2 diabetes mellitus (T2DM). To identify the splicing factor expression that predicts T2DM remission in coronary heart disease (CHD) patients, we identified newly diagnosed T2DM at baseline (<i>n</i> = 190) from the CORDIOPREV study. Patients were classified as Responders (T2DM remission during 5 years without antidiabetic drugs) or non-Responders. Baseline dysregulation in 5 splicing factors (<i>MBNL1</i>, <i>RBM5</i>, <i>hnRNP G/RBMX</i>, <i>CD44</i>, <i>NT5E</i>) distinguished Responders from non-Responders. Adding these factors to clinical variables [AUC = 0.67], insulin resistance, and beta-cell indexes [AUC = 0.76], improved T2DM remission prediction [AUC = 0.80]. Cox regression analysis showed those with higher remission scores had a 2.63-fold increased remission probability. To conclude, a set of splicing factors that contribute to predicting T2DM remission in patients with CHD has been identified. Further research is needed to elucidate these findings' clinical relevance.
Authors
- Ana Ojeda‐Rodríguez (ORCID: https://orcid.org/0000-0001-9755-4322)
- Raul Miguel Luque (ORCID: https://orcid.org/0000-0002-7585-1913)
- Elena M. Yubero‐Serrano (ORCID: https://orcid.org/0000-0002-2733-5359)
- Oriol Alberto Rangel-Zúñiga (ORCID: https://orcid.org/0000-0003-3495-5705)
- José D. Torres‐Peña (ORCID: https://orcid.org/0000-0003-1366-5549)
- José López‐Miranda (ORCID: https://orcid.org/0000-0002-8844-0718)
- Hatim Boughanem (ORCID: https://orcid.org/0000-0001-7743-311X)
- Alicia Podadera-Herreros (ORCID: https://orcid.org/0000-0002-4555-4897)
- Javier Delgado‐Lista (ORCID: https://orcid.org/0000-0002-2982-2716)
- Niki Katsiki (ORCID: https://orcid.org/0000-0003-0894-2644)
- Miguel E. G-García (ORCID: https://orcid.org/0000-0001-6941-6715)
- Antonio P. Arenas‐de Larriva
- Pablo Pérez‐Martínez (ORCID: https://orcid.org/0000-0001-7716-8117)
- Alejandro López‐Moreno (ORCID: https://orcid.org/0000-0001-5620-6129)
Institutions
- International Hellenic University (GR)
- European University Cyprus (CY)
- Instituto de Salud Carlos III (ES)
- Instituto de la Grasa (ES)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Hospital Universitario Reina Sofía (ES)
- University of Córdoba (ES)
- Cordoba University (US)
Publication Details
- Journal
- iScience
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1016/j.isci.2024.111527
- Citations
- 1
- Primary Topic
- Bariatric Surgery and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Fundación Patrimonio Comunal Olivarero
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III