Genomic and clinical characterization of pediatric lymphoepithelioma-like carcinoma
Our findings indicate a promising response rate associated with the combination of PD-1 antibody treatment and chemotherapy in pediatric patients with LELC, providing a theoretical basis for targeting DNA repair pathways. These outcomes suggest that clinical trials involving immune checkpoint inhibitors are warranted in pediatric patients with LELC.
Authors
- Feifei Sun (ORCID: https://orcid.org/0000-0001-9539-1451)
- Suying Lü (ORCID: https://orcid.org/0000-0001-8117-3533)
- Junting Huang (ORCID: https://orcid.org/0000-0002-2448-5837)
- Jia Zhu
- Zijun Zhen (ORCID: https://orcid.org/0000-0002-4442-0897)
- Xiuxia Lu (ORCID: https://orcid.org/0000-0002-1620-197X)
- Yizhuo Zhang (ORCID: https://orcid.org/0000-0002-6128-3476)
- Li Zhang (ORCID: https://orcid.org/0009-0001-3828-8113)
- Yi Que
- Juan Wang (ORCID: https://orcid.org/0000-0003-0767-5687)
- Liping Li (ORCID: https://orcid.org/0000-0001-9002-1988)
- Fenghua Wang (ORCID: https://orcid.org/0000-0001-9670-1036)
- Min Gao (ORCID: https://orcid.org/0000-0003-0553-1153)
- Liang Yu (ORCID: https://orcid.org/0009-0007-3922-3454)
- Wei Liu (ORCID: https://orcid.org/0000-0003-2018-7004)
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Women and Children Medical Center (CN)
- Sun Yat-sen University Cancer Center (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s12967-024-05921-1
- Citations
- 2
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Sun Yat-sen University
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities