Comparative Proteomic Analysis of Endolymphatic Sac Luminal Fluid in Patients with Meniere’s Disease and Controls
The increased levels of IGLV 3-9 and IGLV1-47 in MD group compared with control group suggested an increased inflammatory reactions and a decreased level of Aldehyde dehydrogenase 2 in MD group compared with control group might result in oxidative damage and inflammatory lesions in the ES of MD. Whereas CD44 identified exclusively in MD samples might be involved in the metabolism of its ligand, hyaluronic acid for overproduction of endolymph in the ES of MD.
Authors
- Anquan Peng (ORCID: https://orcid.org/0000-0001-5010-5730)
- Zhou Zhou (ORCID: https://orcid.org/0000-0003-3007-5786)
- Qin Wang (ORCID: https://orcid.org/0000-0001-7603-7166)
- Zhiwen Zhang (ORCID: https://orcid.org/0000-0002-3907-4790)
- Wenqi Jiang (ORCID: https://orcid.org/0000-0002-2546-6814)
Institutions
- Central South University (CN)
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Second Xiangya Hospital of Central South University (CN)
- State Key Laboratory of Oncology in South China
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s474910
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China