Synthesis, DFT, ADMET and molecular docking studies of thiazole derived thiazolidinone-based chalcone derivatives: alzheimer’s disease current therapies
Analog <b>5</b> (IC<sub>50</sub> = <b>1.2 ± 0.1 µM and 1.8 ± 0.2</b> µM) exhibit excellent inhibition in comparison with the standard drug donepezil in view of inhibiting Alzheimer's disease.
Authors
- Gaurav Gupta (ORCID: https://orcid.org/0000-0002-7080-5635)
- Sami I. Alzarea (ORCID: https://orcid.org/0000-0003-4007-4023)
- Ehssan Moglad (ORCID: https://orcid.org/0000-0002-1076-9740)
- Khushi Muhammad (ORCID: https://orcid.org/0000-0003-4425-4742)
- Imran Kazmi (ORCID: https://orcid.org/0000-0003-1881-5219)
- Fazal Rahim (ORCID: https://orcid.org/0000-0001-5856-4886)
- Muhammad Afzal (ORCID: https://orcid.org/0000-0003-2570-3223)
- Shoaib Khan (ORCID: https://orcid.org/0000-0001-5404-0954)
- Muhammad Nadeem (ORCID: https://orcid.org/0000-0001-8600-5563)
- Jalaluddin Azam Khan
Institutions
- Prince Sattam Bin Abdulaziz University (SA)
- King Abdulaziz University (SA)
- Jouf University (SA)
- Hazara University (PK)
- Abbottabad University of Science and Technology (PK)
- Batterjee Medical College
- Saveetha University (IN)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1080/17568919.2024.2421158
- Citations
- 2
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.90