Dexamethasone alleviates acute lung injury in a rat model with venovenous extracorporeal membrane oxygenation support
Our findings suggest that adjuvant Dex treatment during VV ECMO could alleviate ALI and pulmonary inflammation by activating the Hippo/YAP signalling pathway, which promoted alveolar regeneration and AT2 differentiation.
Authors
- Jian-Bao Yang
- Yuanlin Li
- Ran Zhang (ORCID: https://orcid.org/0000-0002-3452-8917)
- Kerong Zhai (ORCID: https://orcid.org/0000-0002-6017-5668)
- Shilin Wei (ORCID: https://orcid.org/0000-0002-0596-2888)
- Bin Li (ORCID: https://orcid.org/0000-0002-8607-8874)
- Xiangyang Wu (ORCID: https://orcid.org/0000-0001-9284-2720)
- Juan Du (ORCID: https://orcid.org/0000-0002-4474-1199)
Institutions
- Chinese PLA General Hospital (CN)
- Lanzhou University Second Hospital (CN)
- Shenzhen Children's Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- BMJ Open Respiratory Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1136/bmjresp-2024-002394
- Citations
- 4
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 1.30
Funders
- Lanzhou University