Ru(III)-PhI(OAc)<sub>2</sub>─A Combination for Generation of Isocyanate Intermediate from Benzimidate through a Rearrangement: Synthesis of Unsymmetrical Urea, Carbamate, and Chiral Analogues
Ru(III)-PhI(OAc)<sub>2</sub>, an unprecedented combination, is a highly efficient reagent system for the in situ generation of a valuable isocyanate intermediate from benzimidate synthons through a rearrangement. It unlocks a powerful platform for forming diverse C-N bonds, enabling the one-pot synthesis of an expansive array of valuable unsymmetrical ureas, carbamates, and their chiral analogues toward complex molecular structures with high selectivity and excellent yields. This new strategy not only exemplifies efficiency but also serves as a versatile tool for the construction of valuable molecular architectures, enhancing the scope and impact of modern synthetic chemistry.
Authors
- Maitreyi Saha
- Dilip K. Maiti (ORCID: https://orcid.org/0000-0001-8743-2620)
- Shobhon Aich
- Saikat Khamarui (ORCID: https://orcid.org/0000-0001-6785-0227)
- Sabir A. Molla
- Rajjakfur Rahaman (ORCID: https://orcid.org/0000-0002-1300-0734)
- Ankan Kumar Sarkar (ORCID: https://orcid.org/0000-0002-6486-222X)
- Debasish Ghosh (ORCID: https://orcid.org/0000-0001-7162-613X)
- Debanjana Bag
Institutions
- University of Calcutta (IN)
- Indian Association for the Cultivation of Science (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1021/acs.orglett.4c04131
- Citations
- 2
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.36