Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses
Our findings are crucial for formulating effective immunization strategies related to the BCG vaccine and for developing efficacious adult TB vaccines.
Authors
- Xinyue Xu (ORCID: https://orcid.org/0000-0001-7434-690X)
- Qi Ouyang (ORCID: https://orcid.org/0000-0001-9122-420X)
- Zongjie Yao (ORCID: https://orcid.org/0000-0002-4383-1862)
- Jinge Cao
- Mengze Gan (ORCID: https://orcid.org/0000-0002-9663-6737)
- Xionglin Fan (ORCID: https://orcid.org/0000-0001-9754-372X)
- Qing Lei (ORCID: https://orcid.org/0000-0002-6679-1752)
- Yuan Yin (ORCID: https://orcid.org/0000-0001-9654-7374)
- Hui Fu (ORCID: https://orcid.org/0000-0003-3203-3301)
- Xiaosong Lin (ORCID: https://orcid.org/0000-0002-1792-9639)
- Zijie Zhou
- Yueqing Wang
Institutions
- Union Hospital (HK)
- Leiden University Medical Center (NL)
- Wuhan No.1 Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s12967-024-05683-w
- Citations
- 3
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Key Technologies Research and Development Program