Integrative analysis of multi-omics data identified PLG as key gene related to Anoikis resistance and immune phenotypes in hepatocellular carcinoma
Our data underscore the pivotal role of PLG in the development of Anoikis resistance and the immunometabolic phenotype in HCC cells. Furthermore, we present compelling experimental evidence that PLG functions as a significant tumor promoter, suggesting its potential as a target for the formulation of tailored therapeutic strategies for HCC.
Authors
- X. Li (ORCID: https://orcid.org/0000-0002-9728-098X)
- Chenhui Ma (ORCID: https://orcid.org/0000-0001-6254-1441)
- Bofang Wang
- Yuping Bai (ORCID: https://orcid.org/0000-0003-1896-277X)
- Hao Chen (ORCID: https://orcid.org/0000-0003-0018-480X)
- Xueyan Wang (ORCID: https://orcid.org/0000-0002-8764-5658)
- Lei Gao (ORCID: https://orcid.org/0000-0003-2336-976X)
- Yanling Ma (ORCID: https://orcid.org/0000-0001-9025-1804)
- Haiyuan Li (ORCID: https://orcid.org/0000-0002-8898-431X)
- Lin Xiang
- Baohong Gu
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s12967-024-05858-5
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China