The mechanism of sevoflurane affecting ovarian cancer cell proliferation and migration by regulating RNA methylase TRDMT1 to activate the β-catenin pathway
Sevo stimulated APC m5C modification and curbed its expression by up-regulating TRDMT1, which in turn activated the β-catenin pathway to stimulate OC cell cycle, invasion, proliferation, and migration and to suppress apoptosis.
Authors
- Xiaomei Lao (ORCID: https://orcid.org/0000-0001-5767-1823)
- Jia Wang (ORCID: https://orcid.org/0000-0001-5339-8954)
- Ying Pan (ORCID: https://orcid.org/0000-0001-8606-9815)
- Xiaochen Huang (ORCID: https://orcid.org/0000-0002-0261-8192)
- Chengyan He (ORCID: https://orcid.org/0000-0001-9640-4867)
Institutions
- First Bethune Hospital of Jilin University (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1007/s10565-024-09941-x
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.47