Non-invasive MRI of blood-cerebrospinal fluid-barrier function in a mouse model of Alzheimer’s disease: a potential biomarker of early pathology
Our work strongly suggests the involvement of CP in the early stages of AD, before the onset of symptoms and behavioural changes, providing a potential biomarker of pathology.
Authors
- Renata Cruz (ORCID: https://orcid.org/0000-0002-4282-007X)
- Charith Perera
- Tânia Carvalho (ORCID: https://orcid.org/0000-0002-5283-5013)
- Noam Shemesh (ORCID: https://orcid.org/0000-0001-6681-5876)
- Jack A. Wells (ORCID: https://orcid.org/0000-0002-4171-3539)
- David Lee Thomas (ORCID: https://orcid.org/0000-0003-1491-1641)
- Andrada Ianuș (ORCID: https://orcid.org/0000-0001-9893-1724)
Institutions
- Champalimaud Foundation (PT)
- St Thomas' Hospital (GB)
- Wellcome Centre for Human Neuroimaging (GB)
- King's College London (GB)
- NIHR Queen Square Dementia Biomedical Research Unit (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s12987-024-00597-7
- Citations
- 8
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 3.23
Funders
- Wellcome Trust
- “la Caixa” Foundation
- Fundação Champalimaud
- Horizon 2020 Framework Programme
- UCLH Biomedical Research Centre