Nanomedicine based on chemotherapy-induced immunogenic death combined with immunotherapy to enhance antitumor immunity
Briefly, the chemotherapeutic drug paclitaxel can induce breast cancer to induce ICD. The nanomedicine which can deliver PTX, CD47siRNA, and R848 at the same time was prepared by double emulsification. NP/PTX/siCD47/R848 nano-drug can be enriched in the tumor site. The experiment of 4T1 cell tumor-bearing mice shows that the nano-drug can enhance tumor immunogenicity and inhibit breast tumor growth, which provides a new scheme for breast cancer treatment. (Graphical abstract).
Authors
- Kuirong Mao
- Tianmeng Sun (ORCID: https://orcid.org/0000-0003-2261-4532)
- Ruolin Ma
- Haipeng Zhang (ORCID: https://orcid.org/0000-0001-9188-542X)
- Dongxiao Han
- Yi-Chang Chen (ORCID: https://orcid.org/0000-0003-3722-6348)
- Bing Han (ORCID: https://orcid.org/0000-0003-2841-8591)
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Model Animal Research Center (CN)
- Zhengzhou Central Hospital (CN)
- Jilin International Studies University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3389/fphar.2024.1511423
- Citations
- 5
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.87
Funders
- People's Government of Jilin Province
- Jilin University
- Department of Science and Technology of Jilin Province
- First Hospital of Jilin University