Design, synthesis and antifungal activity of novel vanillin derivatives containing thiazole and acylhydrazone moieties
Modification of vanillin through electron-withdrawing group substitution and hydrophobic substitution, followed by condensation with thiazole-4-carbohydrazide, could result in highly active antifungal derivatives. Among them, compound 4a, which exhibited excellent inhibitory activities in vitro and in vivo, could potentially serve as a lead compound. © 2024 Society of Chemical Industry.
Authors
- Zhaonong Hu (ORCID: https://orcid.org/0000-0002-8091-7630)
- Xiaofang Yao (ORCID: https://orcid.org/0000-0002-7980-5391)
- Weiwei Wang (ORCID: https://orcid.org/0000-0001-8698-4474)
- Ding Li (ORCID: https://orcid.org/0000-0003-3130-6099)
- Wenjun Wu (ORCID: https://orcid.org/0000-0002-6502-4893)
- Yu Wang (ORCID: https://orcid.org/0000-0002-8159-8723)
Institutions
- Ministry of Agriculture and Rural Affairs (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Pest Management Science
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1002/ps.8591
- Citations
- 7
- Primary Topic
- Biochemical and biochemical processes
- Type
- article
- Field-Weighted Citation Impact
- 2.70
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Natural Science Basic Research Program of Shaanxi Province