A Study on the Long-Term Use of Shenqi Pill Replacing Fuzi with Wuweizi in Historical Perspectives

This study explores the traditional Chinese medicine formulation Shenqi Pill, originally described in Shanghan Zhabing Lun, and its application in treating kidney deficiency-related ailments. While the pill includes Fuzi, known for its toxicity, concerns arise regarding its long-term use. Historical texts such as Qianjin Yaofang and Zhuhou Beiji Fang suggest substituting Fuzi with Wuweizi for prolonged administration, citing the latter’s safety and therapeutic benefits. Wuweizi not only addresses labor-induced weakness but also nourishes kidney and liver function, possessing a balanced flavor profile with lower toxicity. This research emphasizes the importance of historical literature in guiding safe herbal practices, advocating for the incorporation of Wuweizi in Shenqi Pill to enhance patient safety while maintaining efficacy in treatment.