Modified Oxygen Metabolism Toward “Sunlight‐Friendly” Photodynamic Therapy
Abstract Phototoxicity poses a substantial challenge in photodynamic therapy, resulting in intolerable skin damage, visual impairment, and reduced quality of life. Current coping strategies, primarily focus on avoiding inappropriate photoactivation and developing targeted photosensitizers, have not effectively addressed this problem. Hence, this study aims to develop a “sunlight‐friendly” photodynamic therapy strategy. Here, 1‐methoxyphenazine methosulfate (MPMS) is innovatively identified as a key substance in achieving modified oxygen metabolism. MPMS demonstrates efficient catalytic shuttling under abnormal intracellular H 2 O 2 levels, introducing a novel protective approach for oxygen metabolism and numerous life processes. By controlling MPMS administration, the switch of the photosensitizer states between “ON” (killing tumor cells) and “OFF” (safeguarding normal cells) can be achieved. This approach effectively mitigated phototoxicity and holds the potential for widespread clinical application.
Authors
- Xiaoming Xie (ORCID: https://orcid.org/0000-0002-9891-6927)
- Yahan Ju
- Huifang Zhou (ORCID: https://orcid.org/0000-0002-8636-861X)
- Siwei Yang (ORCID: https://orcid.org/0000-0002-5227-8210)
- Yan Liu (ORCID: https://orcid.org/0000-0001-7571-7784)
- Guqiao Ding (ORCID: https://orcid.org/0000-0003-1674-3477)
- Xianqun Fan (ORCID: https://orcid.org/0000-0002-9394-3969)
- Gang Wang (ORCID: https://orcid.org/0000-0002-2288-3807)
- Haiyang Zhang (ORCID: https://orcid.org/0000-0002-3025-9609)
- Hang Wang (ORCID: https://orcid.org/0000-0003-1787-8533)
- Yongqiang Li (ORCID: https://orcid.org/0000-0002-3338-1845)
- Ping Gu (ORCID: https://orcid.org/0000-0002-2203-1057)
- Jipeng Li (ORCID: https://orcid.org/0000-0002-8319-0334)
- Muyue Yang
- Xuefei Song (ORCID: https://orcid.org/0000-0002-5666-6894)
- Kexin Tan
Institutions
- Ningbo University (CN)
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Institute of Microsystem and Information Technology (CN)
Publication Details
- Journal
- Advanced Functional Materials
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1002/adfm.202414817
- Citations
- 8
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Youth Innovation Promotion Association of the Chinese Academy of Sciences