Integration of Ontogeny-Based Changes for Predicting the Exposure of Diphenhydramine in the Pediatric Population: A PBPK Modeling Approach
These model-based anticipations confirmed the authenticity of the developed pediatric model and enhanced the comprehension of developmental variations on PK of diphenhydramine. This may assist healthcare professionals in ensuring the significance of lifespan applicability in personalized dose regimens, promoting therapeutic efficacy and minimizing side effects in chronic conditions among children.
Authors
- Muhammad Fawad Rasool (ORCID: https://orcid.org/0000-0002-8607-8583)
- Hussain Alqhtani (ORCID: https://orcid.org/0000-0002-1840-4519)
- Faleh Alqahtani (ORCID: https://orcid.org/0000-0003-3924-593X)
- Tanveer Ahmad (ORCID: https://orcid.org/0000-0001-8805-0296)
- Ammara Zamir
Institutions
- Bahauddin Zakariya University (PK)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- King Saud University (SA)
- Institut pour l'avancée des biosciences (FR)
- Najran University (SA)
- Université Grenoble Alpes (FR)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3390/pharmaceutics16121553
- Citations
- 2
- Primary Topic
- Pharmaceutical studies and practices
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- King Saud University