Autoimmune-Like Mechanism in Heart Failure Enables Preventive Vaccine Therapy
We demonstrate that PO-HF is triggered by hemodynamic stress and then sets off an autoimmune-like response against cardiac self-antigens. The antigens can be used to reduce the severity of future-onset disease, via oral tolerization, effectively acting as a protective vaccine.
Authors
- Vasiliki Papadopoulou (ORCID: https://orcid.org/0000-0001-6652-3275)
- Gianluigi Condorelli (ORCID: https://orcid.org/0000-0003-0481-6843)
- Marinos Kallikourdis (ORCID: https://orcid.org/0000-0001-9318-3368)
- Laura Papa (ORCID: https://orcid.org/0000-0001-6564-0496)
- Cristina Panico (ORCID: https://orcid.org/0000-0002-9198-3676)
- Antonio Amoroso (ORCID: https://orcid.org/0000-0002-9437-9407)
- Enrico Lugli (ORCID: https://orcid.org/0000-0002-1964-7678)
- Simone Serio (ORCID: https://orcid.org/0000-0002-7294-2094)
- Arianna Felicetta (ORCID: https://orcid.org/0000-0002-5250-0985)
- E Martini (ORCID: https://orcid.org/0000-0001-7222-3383)
- Marco Vacchiano (ORCID: https://orcid.org/0000-0003-2902-4930)
- Silvia Deaglio (ORCID: https://orcid.org/0000-0003-0632-5036)
- M. Cremonesi (ORCID: https://orcid.org/0000-0002-8817-2186)
- Sergio Marchini (ORCID: https://orcid.org/0000-0003-1783-7651)
- Cecilia Assunta Bonfiglio (ORCID: https://orcid.org/0000-0002-7422-0503)
- Pierluigi Carullo (ORCID: https://orcid.org/0000-0003-0812-7770)
- Gianluca Basso (ORCID: https://orcid.org/0000-0002-8430-4727)
- C. D’Andréa
- Jasper J. P. van Beek (ORCID: https://orcid.org/0000-0001-5888-0125)
- Simone Puccio (ORCID: https://orcid.org/0000-0003-4007-4365)
- C Catalano (ORCID: https://orcid.org/0000-0002-9999-6404)
- Erica Pelamatti
- Desirée Giuliano (ORCID: https://orcid.org/0000-0003-0576-4125)
- Paola Magistroni
- Francesca Fanuele (ORCID: https://orcid.org/0009-0002-6547-6352)
- Naz Tuzger
Institutions
- Humanitas University (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Institute of Genetic and Biomedical Research (IT)
- Department of Medical Sciences (BY)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- IRCCS Humanitas Research Hospital (IT)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1161/circresaha.124.324999
- Citations
- 13
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 5.23