Transcription Factor 21 Regulates Cardiac Myofibroblast Formation and Fibrosis
TCF21 expression is not required to maintain the cell state of CFs in the adult heart. However, preventing the normal downregulation of TCF21 expression with injury reduces myofibroblast formation, cardiac fibrosis, and the acute cardiac hypertrophic response following 1 week of Ang II/phenylephrine stimulation.
Authors
- Ronald J. Vagnozzi (ORCID: https://orcid.org/0000-0002-8027-1809)
- Rajesh K. Kasam
- Susan E. Quaggin (ORCID: https://orcid.org/0000-0002-3706-5727)
- Artem Barski (ORCID: https://orcid.org/0000-0002-1861-5316)
- Jose G. Gomez‐Arroyo (ORCID: https://orcid.org/0000-0001-7292-6206)
- Kathrynne A. Warrick (ORCID: https://orcid.org/0000-0002-9385-3365)
- Michelle A. Sargent (ORCID: https://orcid.org/0000-0002-8069-1686)
- Jeffery D. Molkentin (ORCID: https://orcid.org/0000-0002-3558-6529)
- Yasuhide Kuwabara (ORCID: https://orcid.org/0000-0002-9493-9494)
- Suh‐Chin J. Lin (ORCID: https://orcid.org/0000-0002-4704-8576)
- Stephanie Bowers (ORCID: https://orcid.org/0000-0002-4306-0412)
- Tanya A. Baldwin (ORCID: https://orcid.org/0000-0001-7142-639X)
- Adenike Shittu (ORCID: https://orcid.org/0000-0002-1604-9277)
- Anne Katrine Z. Johansen
- Kelly M. Grimes
Institutions
- Northwestern University (US)
- Cincinnati Children's Hospital Medical Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Cincinnati (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1161/circresaha.124.325527
- Citations
- 15
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 6.03
Funders
- Cincinnati Children's Hospital Medical Center
- National Institutes of Health