Heterogeneous immune landscapes and macrophage dynamics in primary and lung metastatic adenoid cystic carcinoma of the head and neck
Primary and lung metastatic ACC exhibit heterogeneous tumor immune microenvironments. Higher immune cell infiltration in lung metastases is countered by the presence of suppressive tumor-associated macrophages, which may limit effective anti-tumor responses.
Authors
- Ran Gao (ORCID: https://orcid.org/0000-0001-6083-7839)
- Tingyao Ma
- Xiaohong Chen (ORCID: https://orcid.org/0009-0002-3250-5305)
- Xuelian Wang (ORCID: https://orcid.org/0000-0002-4647-3693)
- Yue Zhao (ORCID: https://orcid.org/0000-0003-2869-5257)
- Hongfei Liu (ORCID: https://orcid.org/0000-0001-8539-9054)
- Shujing Zhang
- Guoliang Yang (ORCID: https://orcid.org/0000-0003-0408-1453)
- Lu Kong (ORCID: https://orcid.org/0000-0002-4998-1327)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Genetic Resources Center (JP)
- Institute of Laboratory Animal Science (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3389/fimmu.2024.1483887
- Citations
- 3
- Primary Topic
- Salivary Gland Tumors Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China