A model for monitoring the medication rechallenge system in Queen Savang Vadhana Memorial Hospital

A rechallenge process is crucial for patients who need to use drugs known to cause allergic reactions. Establishing a standardized rechallenge protocol is essential to protect patients and increase the likelihood of using effective medications. This study aimed to evaluate the outcomes of the rechallenge monitoring system implemented at Queen Savang Vadhana Memorial Hospital. In this retrospective study, rechallenges focused on two drugs categories: antimicrobial drugs and non-steroidal anti-inflammatory drugs. The confirmed rechallenge protocol was introduced in 2018, and data from October 2019 and November 2022 were extracted from the hospital’s electronic database. The primary outcome measured was the number of adverse events during rechallenges. Trends in severe allergic reactions were documented, and descriptive statistics were used. Out of 81 total rechallenge events, with a history of 77 mild reactions (95.1%) and 4 serious events (4.9%), only 3 mild reaction (3.7%) occurred. A positive trend in successful rechallenges was observed following the implementation of the monitoring model, along with a decrease in medication error levels B and C. Importantly, no harmful levels D and E were detected. The rechallenge monitoring system improved the chance of safe medication use and reduced the occurrence of seriously adverse drug events.