GSK3β Deficiency Expands Obese Adipose Vasculature to Mitigate Metabolic Disorders
Deletion of GSK3β in adipocytes activates the AMPK/HIF-2α/VEGF/VEGFR2 axis, promoting vasculature expansion within obese AT. This results in a significantly improved local microenvironment, reducing inflammation and effectively ameliorating metabolic disorders associated with obesity.
Authors
- Tsukiko Miyata
- James R. Woodgett (ORCID: https://orcid.org/0000-0003-3731-5797)
- Dongliang Zhu (ORCID: https://orcid.org/0000-0001-9612-4478)
- Ping Tang (ORCID: https://orcid.org/0000-0003-2637-3932)
- Yuan Wang (ORCID: https://orcid.org/0000-0002-5692-2659)
- Lijun Di (ORCID: https://orcid.org/0000-0002-7313-6991)
- Jiajia Li (ORCID: https://orcid.org/0000-0001-6743-2797)
- L.R. Tai
- Li Wang (ORCID: https://orcid.org/0000-0003-2068-7535)
Institutions
- University of Macau (MO)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Abterra Biosciences (United States) (US)
- Precision for Medicine (United States) (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1161/circresaha.124.325187
- Citations
- 14
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.27