The protective role of gamma zone peripapillary atrophy in diabetic retinopathy: insights from deep learning and SS-OCT angiography
This study finds that gamma zone PPA is linked to a reduced risk of developing DR. These results imply that the gamma zone may reflect progressive myopia-associated thinning and microvascular depletion in posterior ocular tissues, potentially contributing to structural resilience against DR. This novel insight offers a promising avenue for understanding the interplay between PPA and DR.
Authors
- Qiyong Zhong (ORCID: https://orcid.org/0009-0004-9843-5260)
- Jiahui Jiang (ORCID: https://orcid.org/0000-0003-0306-3448)
- Na Zhao (ORCID: https://orcid.org/0000-0001-8648-9422)
- X L Ye
- Xinxin Hu (ORCID: https://orcid.org/0009-0002-1049-8597)
- Jun Zhu (ORCID: https://orcid.org/0000-0002-7905-7856)
- Juntao Zhang (ORCID: https://orcid.org/0000-0001-7500-3140)
- Qinkang Lu (ORCID: https://orcid.org/0000-0002-0648-2499)
- Xixi Zhang (ORCID: https://orcid.org/0000-0001-7048-4627)
- Yitian Zhao
- Yingying Li (ORCID: https://orcid.org/0009-0002-2066-9417)
- Weina Ren
- Dandan Wang (ORCID: https://orcid.org/0009-0003-5556-3521)
Institutions
- Ningbo University (CN)
- University of Nottingham Ningbo China (CN)
- Chinese Academy of Sciences (CN)
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Ningbo Institute of Industrial Technology (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3389/fcell.2024.1501625
- Citations
- 1
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningbo
- Natural Science Foundation of Zhejiang Province