Platelet-rich plasma combined with isometric quadriceps contraction regulates autophagy in chondrocytes via the PI3K/AKT/mTOR pathway to promote cartilage repair in knee osteoarthritis
The combined intervention promotes autophagy in chondrocytes by inhibiting the PI3K/AKT/mTOR pathway, downregulating inflammatory factors and MMP-13 in the cartilage, upregulating autophagy markers, inhibiting matrix degradation, and promoting cartilage repair.
Authors
- Yajun Tan (ORCID: https://orcid.org/0000-0002-1168-5098)
- Shuwan Chang (ORCID: https://orcid.org/0000-0002-3937-1701)
- Benxiang He (ORCID: https://orcid.org/0000-0002-0665-8861)
- Liang Cheng (ORCID: https://orcid.org/0000-0003-4105-1763)
Institutions
- Chengdu Sport University (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1016/j.reth.2024.11.013
- Citations
- 5
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.17