Impact of Chronic Stress on Inflammatory Markers and Risk of Metabolic Syndrome: A Longitudinal Study

Stress is also known to suppress the immune system, spread inflammation, and trigger metabolic syndrome.The present study was a longitudinal, retrospective design that was intended to assess the impact of stress management on inflammation and metabolic alterations over three years.The sample consisted of 500 middle-aged persons, of whom 56% were females.PSS, CRP, IL-6, TNF, and metabolic syndrome status were measured at baseline, 18 months, and 36 months.The results showed a decrease in PSS from 22.5 at baseline to 19.2 at 36 months.Inflammatory markers were also reduced with the final values of 3.5 1.2 mg/L for CRP, 6.8 0.8 pg/mL for IL-6, and 10 1 pg/mL for TNF-.Also, the proportion of metabolic syndrome reduced from 30% to 20%.The results of the Pearson correlation coefficient analysis of stress and inflammation markers were negative and suggested that stress will lead to an increase in inflammation markers.The hypothesis was further confirmed by regression analysis where each unit increase in PSS score was associated with a 25% increased risk of metabolic syndrome.These outcomes demonstrate that stress reduction lowers inflammation and metabolic syndrome due to regulating sympathetic and neuroendocrine systems and leads to lower inflammation and cardiometabolic risk.Perceived stress and lifestyle changes may be effective approaches to preventing or reversing metabolic disease.