The complex relationship between the microbiota-gut-brain axis and neurodegenerative diseases and future perspectives

The morbidity and mortality of neurodegenerative diseases (NNDs) are increasing year by year, but the pathogenesis of the diseases is still unclear and the only currently available treatments are very limited. The aging of the world's population is a serious trend, and the search for new treatments is urgent. The discovery of the microbial-gut-brain axis provides new therapeutic ideas. In this paper, we will describe the current mechanism of the microbial-gut-brain axis, and discuss the feasible solutions for the treatment of neurodegenerative diseases by regulating the gut microbiota, in order to provide new ideas for the treatment of neurodegenerative diseases in the future.