Exercise promotes skeletal muscle growth in adolescents via modulating Mettl3-mediated m6A methylation of MyoD in muscle satellite cells
Exercise promoted skeletal muscle growth in adolescents through facilitating MyoD mRNA stability of MuSCs in a Mettl3-mediated m6A-dependent manner. The methyl donor betaine could be a potential alternative to exercise for promoting adolescent skeletal muscle growth by directly augmenting the global levels of m6A methylation. These findings may provide a theoretical foundation for encouraging daily fitness exercise and ensuring healthy growth in adolescents.
Authors
- Xingzuan Lin (ORCID: https://orcid.org/0009-0006-6063-666X)
- Siyuan Zhu (ORCID: https://orcid.org/0000-0002-8559-6290)
- Xiexiang Shao (ORCID: https://orcid.org/0000-0003-4837-1305)
- Hao Zhou (ORCID: https://orcid.org/0009-0000-1276-0080)
- Jianhua Wang (ORCID: https://orcid.org/0000-0001-6831-9593)
- Ru Wang (ORCID: https://orcid.org/0000-0003-1064-9615)
- Huifang Chen (ORCID: https://orcid.org/0000-0002-4572-5879)
- Han Zhou (ORCID: https://orcid.org/0000-0003-4932-8958)
- Shujing Feng
- Peng Wang (ORCID: https://orcid.org/0009-0002-4416-6339)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai University of Sport (CN)
- Peking University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Peking University Third Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s11658-024-00670-x
- Citations
- 9
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Shanghai Advanced Research Institute, Chinese Academy of Sciences