The OGG1 Ser326Cys polymorphism and its association with DNA damage and DNA repair in papillary thyroid cancer
Aim: Hydrogen peroxide, locally produced during thyroid hormone synthesis, leads to oxidative stress in the thyroid gland. Defective repair of oxidative DNA lesions contributes to tumor development. This study aimed to understand the importance of DNA damage and repair on thyroid cancer development through the impact of the DNA repair gene OGG1 Ser326Cys polymorphism that has clinical significance in untreated patients with papillary thyroid cancer. Methods: The study was performed with 70 patients with papillary thyroid cancer and 73 volunteers as control. In lymphocytes, endogenous DNA damage, H2O2-induced DNA damage, and DNA damage after repair were determined by comet assay. The polymerase chain reaction-restriction fragment length polymorphism method was performed for OGG1 genotyping. Results: Endogenous DNA damage, H2O2-induced DNA damage, and DNA damage after repair were higher in patients with thyroid cancer than in the controls (P
Authors
- Hakan Yavuzer (ORCID: https://orcid.org/0000-0003-2685-6555)
- Meltem Mete (ORCID: https://orcid.org/0000-0002-9297-8254)
- Ali Ata Tuz (ORCID: https://orcid.org/0000-0002-9802-2317)
- Selen Soylu (ORCID: https://orcid.org/0000-0002-1459-399X)
- Serap Yavuzer (ORCID: https://orcid.org/0000-0001-7618-9987)
- Mehmet Güven (ORCID: https://orcid.org/0000-0002-8749-1708)
- Çağlayan Akkaya (ORCID: https://orcid.org/0000-0002-1905-0775)
- Yıldız Dinçer (ORCID: https://orcid.org/0000-0002-8393-7901)
- Serkan Teksöz (ORCID: https://orcid.org/0000-0002-6733-5644)
Institutions
- Istanbul Aydın University (TR)
- Istanbul University-Cerrahpaşa (TR)
- Istinye University (TR)
- İstanbul Esenyurt Üniversitesi
Publication Details
- Journal
- Anadolu Kliniği Tıp Bilimleri Dergisi
- Published
- 2024-12-04
- DOI
- https://doi.org/10.21673/anadoluklin.1508336
- Primary Topic
- Glutathione Transferases and Polymorphisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00