Effect of fluid and driving pressure on cyclical “on–off” flow of pulmonary microcirculation during mechanical ventilation
The difference in alveolar perfused microcirculation between inspiration and expiration defined as cyclical "on-off flow" can be detected. High driving pressure can enhance the cyclical "on-off" flow, and fluid loading can relieve it. High driving pressure can potentially cause injury to pulmonary capillaries due to the phenomenon of "on-off" flow, thereby exacerbating ARDS.
Authors
- Haoping Huang
- Huaiwu He (ORCID: https://orcid.org/0000-0003-3422-3109)
- Yi Chi (ORCID: https://orcid.org/0000-0002-0948-9311)
- Longxiang Su (ORCID: https://orcid.org/0000-0002-0942-2870)
- Şakir Akın (ORCID: https://orcid.org/0000-0003-0700-1930)
- Siyi Yuan (ORCID: https://orcid.org/0000-0002-0140-1282)
- Chaofu Yue (ORCID: https://orcid.org/0000-0002-7610-9526)
- Liangyu Mi (ORCID: https://orcid.org/0009-0004-3958-897X)
- Can İnce (ORCID: https://orcid.org/0000-0002-8298-0270)
- Yun Long (ORCID: https://orcid.org/0000-0002-9196-4651)
- Zeming Zhao
- Xiangyu Chen (ORCID: https://orcid.org/0000-0002-3618-5954)
- Bo Liu (ORCID: https://orcid.org/0000-0002-2769-5354)
Institutions
- Jiamusi University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Erasmus MC (NL)
- Haga Hospital (NL)
- Jingzhou Central Hospital (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s40635-024-00689-6
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking Union Medical College Hospital