Behavioral decline in Shank3Δex4–22 mice during early adulthood parallels cerebellar granule cell glutamatergic synaptic changes
Our findings reveal an age-related exacerbation of behavioral impairments in Shank3<sup>Δex4-22</sup> mutant mice. These results suggest that Shank3 may alter the function of glutamatergic receptors at the mossy fiber-cerebellar granule cell synapse as a potential mechanism causing cerebellar disruption in ASD.
Authors
- B. D. Richardson (ORCID: https://orcid.org/0000-0003-0403-4956)
- Romana Hyde (ORCID: https://orcid.org/0000-0002-0668-5026)
- Rajaram Kshetri (ORCID: https://orcid.org/0000-0002-7866-745X)
- James O. Beavers
- Roseline Ewa
- Amber Schwertman
- Sarahi Porcayo
Institutions
- University of Idaho (US)
- Southern Illinois University School of Medicine (US)
Publication Details
- Journal
- Molecular Autism
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s13229-024-00628-y
- Citations
- 7
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- National Institutes of Health