Multimodal genome-wide survey of progressing and non-progressing breast ductal carcinoma in-situ
DCIS is a molecularly highly heterogenous disease with variable outcomes, and the molecular events determining DCIS disease progression remain poorly defined. Our genome-wide multi-omic survey documents DCIS-associated alterations and reveals molecular heterogeneity within the intrinsic DCIS subtypes. Further studies investigating intrinsic subtype-stratified characteristics and molecular signatures are needed to determine if these may be exploitable for risk assessment and mitigation of DCIS progression. The highly significant associations of specific gene sets with IBC progression revealed by our Gene Set Enrichment Analysis may lend themselves to the development of a prognostic molecular score, to be validated on independent DCIS cohorts.
Authors
- Katherine A. Hoadley (ORCID: https://orcid.org/0000-0002-1216-477X)
- Leslie Cope (ORCID: https://orcid.org/0000-0002-4098-3289)
- Michael Considine (ORCID: https://orcid.org/0000-0002-8666-4857)
- Brenda Y. Hernandez (ORCID: https://orcid.org/0000-0003-0132-4042)
- P. J. van Diest (ORCID: https://orcid.org/0000-0003-0658-2745)
- Wendy Cozen (ORCID: https://orcid.org/0000-0003-3415-8247)
- Soonweng Cho (ORCID: https://orcid.org/0000-0002-1637-2875)
- Ashley Cimino‐Mathews (ORCID: https://orcid.org/0000-0002-0638-7969)
- Yongchun Wang (ORCID: https://orcid.org/0000-0002-8297-2908)
- Brittany Avin-McKelvey
- Christopher B. Umbricht (ORCID: https://orcid.org/0000-0002-1993-0553)
- Liliana Florea (ORCID: https://orcid.org/0000-0001-8124-2324)
- Marija Debeljak (ORCID: https://orcid.org/0000-0002-4865-2820)
- William E. Grizzle (ORCID: https://orcid.org/0000-0001-9245-0401)
- Phillip N. Perez (ORCID: https://orcid.org/0000-0001-7189-0133)
- Debra Hawes (ORCID: https://orcid.org/0000-0001-5936-4835)
- Charles F. Lynch (ORCID: https://orcid.org/0000-0002-9542-6439)
- Bradley M. Downs (ORCID: https://orcid.org/0000-0001-6156-510X)
- Ann S. Hamilton (ORCID: https://orcid.org/0000-0001-5898-2308)
- Edward Gabrielson
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Southern California (US)
- University of Hawaiʻi at Mānoa (US)
- University of Iowa (US)
- University of Hawaii System (US)
- Children's Hospital of Los Angeles (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University Medical Center Utrecht (NL)
- University of Alabama at Birmingham (US)
- Cancer Research Center (US)
- University of Baltimore (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s13058-024-01927-1
- Citations
- 4
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- National Institutes of Health
- Holden Comprehensive Cancer Center, University of Iowa
- National Cancer Institute