Chemically Defined Organoid Culture System for Cholangiocyte Differentiation (Adv. Healthcare Mater. 30/2024)

CholangioCyte organoidsThe jewelry box presents the chemically defined hydrogel (PIC) used for cholangiocyte organoid culture.The ring presents the PIC-cultured organoids; these organoids possess more mature cholangiocyte characteristics, such as bile acid (BA) homeostasis depicted on the box surface.Moreover, these mature cholangiocyte organoids effectively modeled the biliary pro-fibrotic response induced by TGF.This model is like a diamond ring that will shine on the path of scientific research and preclinical drug screening.More details can be found in article 2401511 by Rosalinde Masereeuw, Bart Spee, and co-workers.