Assessment of the Effects of Stone Herbal Mixture Drink on Liver Parameters

Background: Herbal treatments have been used for ages, across many countries and traditions to maintain health and treat diseases. Herbal medicines are sometimes seen as all-natural substitutes for traditional drugs, providing a possible means of advancing health and fitness. Investigating how herbal mixes affect various physiological characteristics, such as liver function, has drawn more attention in recent years. The stone herbal concoction under examination is made up of a number of plant-based ingredients, with unique therapeutic effects. Methods: Thirty-six (36) wistar rats in total, split into six (6) groups of six (6) animals each, participated in this experimental study: In Group 1, the control group received only water and top feed; in Group 2, the standard medication (Sylimarin, 140 mg/kg body weight) plus 0.30 ml of stone herbal mixture was given; in Group 3, 0.30 ml of stone herbal mixture was given; in Group 4, 0.25 ml was given; in Group 5, 0.20 ml was given; and in Group 6, 0.15 ml was given. The rats were ethically sacrificed by cervical dislocation after receiving the daily therapy for 21 days. Each rat's brachiocephalic artery was used to draw blood, which was then placed in a lithium haparin anticoagulant bottle and examined for liver parameters. Results: Group 3, 4, 5 & 6 which contains 1000mg, 850mg, 650mg and 500mg of the stone herbal mixture showed significant increase of all liver enzymes when compared to the control group. Also, the group two administered with 1000mg of the stone herbal mixture and 140 mg of the standard drug, sylimarine totally reversed toxicity in all the liver function parameters (ALT, AST, ALP, GGT, Albumin, Total protein, Bilirubin, AFP, TNF) compared to the control group one. Groups 3, 4, 5 and 6 which contains 1000mg, 850mg, 650mg and 500mg of the stone herbal mixture showed significant decrease of Albumin, bilirubin and total protein with while the 500mg dose of herbal mixture in group 6 was increased. Conclusion: In conclusion, this study has unveiled valuable insights into the effects of the Stone Herbal Mixture on liver parameters in male albino Wistar rats. Our result demonstrated that the lowest dose of the stone herbal mixture which is 500 mg is tolerable with the liver as against other higher doses in this experiment.