The Clinical Impact of NPM1 Mutations and the Effect of Concurrent Mutations in Acute Myeloid Leukemia: Unraveling the Prognostic Significance
The evaluation of <i>NPM1</i> <sup>mut</sup> and co-mutation has consistently demonstrated remarkable prognostic significance in AML, suggesting the potential for improved response rates, extended disease-free periods, and OS. Our findings provide valuable insights for understanding molecular leukemogenesis in AML-NK patients and will aid in clinical diagnosis, prognostic implications, and the development of targeted therapy strategies for Syrian AML patients.
Authors
- Yahia Moualla (ORCID: https://orcid.org/0000-0002-4609-6533)
- Faten Moassass
- Atieh Khamis
- Bassel Al‐Halabi
- Walid Al‐Achkar
Institutions
- Latakia University (SY)
- Atomic Energy Commission of Syria (SY)
Publication Details
- Journal
- Health Science Reports
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/hsr2.70231
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tishreen University
- Atomic Energy Commission of Syria