DNA methylation-based telomere length is more strongly associated with cardiovascular disease and long-term mortality than quantitative polymerase chain reaction-based telomere length: evidence from the NHANES 1999–2002
Longer DNAmTL was positively correlated with reduced CVD risk and long-term mortality in middle-aged and elderly cohorts. Notably, DNAmTL outperformed qPCRTL as an aging biomarker in the stratification of CVD risks and mortality.
Authors
- Huanhuan Ding (ORCID: https://orcid.org/0009-0001-9865-8585)
- Baopeng Tang (ORCID: https://orcid.org/0009-0005-4650-3265)
- Jie Song (ORCID: https://orcid.org/0000-0002-4711-6014)
- Xianhui Zhou (ORCID: https://orcid.org/0009-0000-2399-3592)
- Yuanfeng Gao (ORCID: https://orcid.org/0000-0003-2130-2772)
- Xinchun Yang (ORCID: https://orcid.org/0000-0001-9568-9100)
- Qianhui Wang (ORCID: https://orcid.org/0000-0002-1876-0310)
- Dilare Taiwaikuli
Institutions
- Xinjiang Medical University (CN)
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s13148-024-01795-8
- Citations
- 7
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- National Natural Science Foundation of China