The Usage of an Amniotic Membrane to Minimize Pathological Scarring in Nerve Neurotization Surgery

Despite modern advances in surgery, the problem of pathological scarring is still remains relevant. It can lead to both serious dysfunctions of various organ systems and cosmetic defects, which significantly reduces the quality of patients’ life. In search of effective methods for the prevention of scarring, we paid attention to the amniotic sac, which, due to its properties, is able to provide tissue protection and prevent scar-adhesive processes. We have illustrated the positive results of the amnion usage in surgery of sciatic nerve neurotization in rabbits; a safety and effectiveness of this method have been also presented. The amniotic sac is a promising biomaterial for the prevention of pathological scarring and improvement of postoperative outcomes. However, further research and standardization of production are needed for its widespread use.