Asparagus officinalis L. extract exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells and a transgenic mouse model of endometrial cancer
These findings provide strong preclinical evidence for the potential therapeutic benefit of <i>asparagus officinalis</i> extract as a novel dietary strategy in the treatment of endometrial cancer. Further clinical trials of dietary intervention of <i>asparagus officinalis</i> or combination with cisplatin in patients with endometrial cancer are warranted.
Authors
- Luyu Zhao
- Victoria Bae‐Jump (ORCID: https://orcid.org/0000-0001-6778-0951)
- Leslie H. Clark (ORCID: https://orcid.org/0000-0002-2551-760X)
- Stephanie A. Sullivan (ORCID: https://orcid.org/0000-0003-1852-6062)
- Weimin Kong (ORCID: https://orcid.org/0000-0002-4429-3242)
- Jiandong Wang (ORCID: https://orcid.org/0000-0002-1466-9798)
- Delin Sun
- Guangxu Xu (ORCID: https://orcid.org/0000-0002-8448-6073)
- Ziwei Fang (ORCID: https://orcid.org/0000-0002-1639-0176)
- Ziyi Zhao (ORCID: https://orcid.org/0000-0003-1871-5197)
- Arthur-Quan Tran
- Changsheng Zhou (ORCID: https://orcid.org/0000-0002-4297-364X)
- Wenchuan Sun
Institutions
- University of North Carolina at Chapel Hill (US)
- Capital Medical University (CN)
- Shanghai University of Medicine and Health Sciences (CN)
- Beijing Obstetrics and Gynecology Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.3389/fphar.2024.1507042
- Citations
- 3
- Primary Topic
- Phytochemical Studies and Bioactivities
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Chinese Academy of Sciences
- Capital Medical University
- National Institutes of Health
- Beijing Obstetrics and Gynecology Hospital, Capital Medical University
- National Cancer Institute