Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety
Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging the two disorders. However, the significant heterogeneity of most bridging symptoms presents challenges for psychopathological interpretation and clinical applicability. Here, we conceptually established a common bridging factor (cb factor) to characterize a general structure of these bridging symptoms, analogous to the general psychopathological p factor. We identified a cb factor from 12 bridging symptoms in depression-anxiety comorbidity network. Moreover, this cb factor could be predicted using edge-centric connectomes with robust generalizability, and was characterized by connectome patterns in attention and frontoparietal networks. In an independent twin cohort, we found that these patterns were moderately heritable, and identified their genetic connectome-transcriptional markers that were associated with the neurobiological enrichment of vasculature and cerebellar development, particularly during late-childhood-to-young-adulthood periods. Our findings revealed a general factor of bridging symptoms and its neurobiological architectures, which enriched neurogenetic understanding of depression-anxiety comorbidity.
Authors
- Shaozheng Qin (ORCID: https://orcid.org/0000-0002-1859-2150)
- L. Xia (ORCID: https://orcid.org/0000-0001-9757-8172)
- Yuan Zhou (ORCID: https://orcid.org/0000-0001-6378-1711)
- Xuerong Liu (ORCID: https://orcid.org/0000-0002-9236-5773)
- Qinghua He (ORCID: https://orcid.org/0000-0001-6396-6273)
- Ting Xu (ORCID: https://orcid.org/0000-0003-1590-9025)
- Zhibing Xiao (ORCID: https://orcid.org/0000-0002-0457-0233)
- Jiang Hua Qiu (ORCID: https://orcid.org/0000-0003-0269-5910)
- Xu Lei (ORCID: https://orcid.org/0000-0003-2271-1287)
- Yuanyuan Hu (ORCID: https://orcid.org/0000-0001-6788-702X)
- Tingyong Feng (ORCID: https://orcid.org/0000-0001-9278-6474)
- Bowen Hu (ORCID: https://orcid.org/0000-0002-5446-5669)
- Wei Li (ORCID: https://orcid.org/0000-0002-4970-7619)
- Hong Chen (ORCID: https://orcid.org/0000-0001-8888-5103)
- Jingxuan Zhang (ORCID: https://orcid.org/0000-0002-8979-5107)
- Chen Ji
- Zhiyi Chen (ORCID: https://orcid.org/0000-0003-1744-4647)
- Zhengzhi Feng (ORCID: https://orcid.org/0000-0001-6144-5044)
- Rong Zhang (ORCID: https://orcid.org/0000-0003-4516-4116)
- Yancheng Tang
Institutions
- Shanghai International Studies University (CN)
- Southwest University (CN)
- McGovern Institute for Brain Research (US)
- University of Electronic Science and Technology of China (CN)
- Army Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Beijing Normal University (CN)
- Institute of Computing Technology (CN)
- Ministry of Education (KR)
- Chinese Institute for Brain Research (CN)
- Institute of Psychology, Chinese Academy of Sciences (CN)
- Sichuan Provincial Hospital of Traditional Chinese Medicine (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1038/s41467-024-55008-0
- Citations
- 13
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.46
Funders
- National Natural Science Foundation of China
- Southwest University
- Centre Scientifique et Technique du Bâtiment
- National Key Research and Development Program of China