Pharmacokinetics of cefiderocol in a patient with carbapenem‐resistant <i>Acinetobacter baumannii</i> ventriculitis: A case report
We observed minimal fluctuation of cefiderocol concentrations in CSF, questioning the conventional reliance on CSF/serum area under the curve (AUC) ratio as a measure of CNS penetration. Our experience suggests that a single CSF concentration (random or trough) could be directly compared to the minimum inhibitory concentration, offering a potentially simpler approach to evaluate dosing adequacy.
Authors
- William R. Miller (ORCID: https://orcid.org/0000-0002-1518-2973)
- Adarsh Bhimraj (ORCID: https://orcid.org/0009-0005-5008-3128)
- Vincent H. Tam (ORCID: https://orcid.org/0000-0001-7071-5376)
- Alejandro Granillo (ORCID: https://orcid.org/0000-0002-8044-6752)
- Nazanin Pouya
- Natalie A. Finch (ORCID: https://orcid.org/0009-0009-0888-5943)
Institutions
- Methodist Hospital (US)
- University of Houston (US)
Publication Details
- Journal
- Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1002/phar.4632
- Citations
- 3
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- Houston Methodist Hospital
- National Institutes of Health
- Houston Methodist Research Institute