Concise total synthesis of (±)-applanatumol Y
Total synthesis of (±)-applanatumol Y was achieved in 5 steps, featuring a cascade annulation including Michael addition, aldol condensation, and oxy-Michael addition reactions, all promoted by DBU. This approach offers a streamlined and cost-effective route for constructing complex tricyclic frameworks under mild and metal-free conditions.
Authors
- Hong‐Bo Qin (ORCID: https://orcid.org/0000-0003-2603-9520)
- Jin Li (ORCID: https://orcid.org/0000-0001-6887-7720)
- Mingwei Yuan (ORCID: https://orcid.org/0000-0002-6657-5048)
- Wan-Ning Yuan
- Song-Juan Luo
- Zhao-Nan Cai
Institutions
- Minzu University of China (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1039/d4ob01763c
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00