A genome‐wide association study of European advanced cancer patients treated with opioids identifies regulatory variants on chromosome 20 associated with pain intensity
This genome-wide association study on European advanced cancer patients treated with opioids identifies novel regulatory variants on chromosome 20 (near PCMTD2 and OPRL1 genes) associated with pain intensity. These findings enhance our understanding of the genetic basis of opioid response, suggesting new potential markers for opioid efficacy. The study is a significant advancement in pharmacogenomics, providing a robust dataset and new insights into the genetic factors influencing pain intensity, which could lead to personalized cancer pain management.
Authors
- Pål Klepstad (ORCID: https://orcid.org/0000-0003-2804-8447)
- Augusto Caraceni (ORCID: https://orcid.org/0000-0002-0375-6204)
- Frank Skorpen (ORCID: https://orcid.org/0000-0001-7093-8000)
- Oscar Corli (ORCID: https://orcid.org/0000-0002-5282-8657)
- Francesca Colombo (ORCID: https://orcid.org/0000-0003-2015-4317)
- Francesca Minnai (ORCID: https://orcid.org/0000-0003-3646-3800)
- Marco Maltoni (ORCID: https://orcid.org/0000-0002-4604-9825)
- Ernesto Zecca (ORCID: https://orcid.org/0000-0003-1689-0370)
- Morena Shkodra (ORCID: https://orcid.org/0000-0001-6543-7738)
- Alessandra Pigni (ORCID: https://orcid.org/0000-0003-1869-965X)
- Sara Noci (ORCID: https://orcid.org/0000-0002-6227-3907)
- Cinzia Brunelli (ORCID: https://orcid.org/0000-0003-3905-1289)
- Maria Caterina Pallotti (ORCID: https://orcid.org/0000-0002-6629-262X)
- Martina Esposito (ORCID: https://orcid.org/0009-0007-4118-3893)
- Stein Kaasa (ORCID: https://orcid.org/0000-0002-3268-8036)
Institutions
- Oslo University Hospital (NO)
- University of Oslo (NO)
- University of Milan (IT)
- Mario Negri Institute for Pharmacological Research (IT)
- Norwegian University of Science and Technology (NO)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- St Olav's University Hospital (NO)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Institute of Biomedical Technologies (IT)
- National Research Council (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- University of Bologna (IT)
Publication Details
- Journal
- European Journal of Pain
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1002/ejp.4764
- Citations
- 2
- Primary Topic
- Pain Management and Opioid Use
- Type
- article
- Field-Weighted Citation Impact
- 1.28
Funders
- Associazione Italiana per la Ricerca sul Cancro