SGLT2 inhibitor downregulates ANGPTL4 to mitigate pathological aging of cardiomyocytes induced by type 2 diabetes
Collectively, our study demonstrates that SGLT2i ameliorate the pathological aging of cardiomyocytes induced by a high glucose and high fat metabolic milieu by regulating the interaction between FOXO1 and ANGPTL4, thereby suppressing the transcriptional synthesis of the latter, and consequently restoring cardiac function.
Authors
- Haowen Ye
- Caixia Ma
- Xian Yang (ORCID: https://orcid.org/0000-0001-7461-3991)
- Liangyan Wu (ORCID: https://orcid.org/0009-0002-2528-4313)
- Ruxin Wang (ORCID: https://orcid.org/0000-0003-4772-3284)
- Tianqi Duo (ORCID: https://orcid.org/0000-0001-9211-4125)
- Yongting Zhao (ORCID: https://orcid.org/0000-0002-7864-4434)
- Ying Wang (ORCID: https://orcid.org/0000-0002-7852-386X)
- Jiaxin Wang (ORCID: https://orcid.org/0000-0003-3132-6663)
- Lihong Wang (ORCID: https://orcid.org/0000-0002-0579-6912)
- Xiaofang Zhang (ORCID: https://orcid.org/0000-0001-7184-1526)
- Yun Wen
- Han Liu
- Meixin Yu
Institutions
- Jinan University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s12933-024-02520-8
- Citations
- 16
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China
- Jinan University