Human adenovirus type 7 (HAdV-7) infection induces pulmonary vascular endothelial injury through the activation of endothelial autophagy
HAdV-7 successfully infects pulmonary vascular endothelium and replicates effectively, causing injury to the endothelium, high VEGF expression and viral load in the serum, as well as ALI/ARDS. Autophagy inhibitors can alleviate endothelial injury, inhibit viral replication, relieve leakage from the vasculature, and reduce lung inflammation.
Authors
- Na Zang (ORCID: https://orcid.org/0000-0001-6658-6700)
- Changgen Li (ORCID: https://orcid.org/0000-0001-7671-5705)
- Zhongying Yang (ORCID: https://orcid.org/0000-0003-4686-0869)
- Enmei Liu (ORCID: https://orcid.org/0000-0001-8503-6974)
- zhihe Chen
- Lifen Rao
Institutions
- Guizhou Provincial People's Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-12-04
- DOI
- https://doi.org/10.1186/s12931-024-03025-4
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- National Natural Science Foundation of China
- Chongqing Science and Technology Commission