Generation of primary feline chimeric antigen receptor T cells
CAR T therapy has been used with great success for human hematologic malignancies and is under development for use in canines. Our study is the first demonstration of functional feline CAR T cells and describes the procedures for their engineering. These findings lay the foundation for future development of CAR T therapy for multiple feline diseases.
Authors
- James R. Cockey (ORCID: https://orcid.org/0000-0001-6227-2077)
- Christian Urbina
- Cynthia A. Leifer (ORCID: https://orcid.org/0000-0003-0987-9747)
- G Zhou
- Emily N. Kulp
- Christina Kerkenpaß
Institutions
- Cornell University (US)
Publication Details
- Journal
- American Journal of Veterinary Research
- Published
- 2024-12-04
- DOI
- https://doi.org/10.2460/ajvr.24.08.0247
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00