Geraniol Ameliorates Pentylenetetrazol-Induced Epilepsy, Neuroinflammation, and Oxidative Stress via Modulating the GABAergic Tract: In vitro and in vivo studies
Ger reduced the oxidative stress status, neuroinflammation and apoptosis and activated GABAergic neurotransmission, which might clarify its anticonvulsant. Ger protects animals against PTZ prompted kindling as established by the enhancement in short term as well as long-term memory. Ger mitigated the injury induced by Glu in NGF prompted PC12 cell.
Authors
- Maged E. Mohamed (ORCID: https://orcid.org/0000-0002-1216-8703)
- Mervt M. Almostafa (ORCID: https://orcid.org/0000-0003-0187-0772)
- Nancy S. Younis (ORCID: https://orcid.org/0000-0003-4309-7095)
Institutions
- Zagazig University (EG)
- King Faisal University (SA)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/dddt.s481985
- Citations
- 8
- Primary Topic
- Medicinal Plants and Neuroprotection
- Type
- article
- Field-Weighted Citation Impact
- 5.73